Abstract
The methanol, acetone and N, N-dimethylformamide extracts of Terminalia catappa L. leaf were evaluated for antibacterial and antifungal activity. Piperacillin and gentamicin were used as standards for antibacterial assay, while nystatin and flucanazole were used as standards for antifungal assay. 91 clinically important strains were used for the study which were both clinical isolates as well as identified strains. The antimicrobial activity of all the extracts was determined by agar disc diffusion method. The antibacterial activity was more pronounced against bacteria than fungal strains. The Gram positive bacteria were more susceptible than Gram negative bacteria. The methanol extract showed best antibacterial activity. T. catappa leaf extracts showed better antibacterial activity than commercially used antibiotics.
Highlights
Traditional medicine has been practiced for many centuries in many parts of the world, including Bangladesh especially in rural areas due to availability and low cost
Piperacillin and gentamicin were used as standards for antibacterial assay, while nystatin and flucanazole were used as standards for antifungal assay. 91 clinically important strains were used for the study which were both clinical isolates as well as identified strains
Nature has provided a source of medicinal agents for thousands of years and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine [1]
Summary
Traditional medicine has been practiced for many centuries in many parts of the world, including Bangladesh especially in rural areas due to availability and low cost. Nature has provided a source of medicinal agents for thousands of years and an impressive number of modern drugs have been isolated from natural sources, many based on their use in traditional medicine [1]. Numerous studies have been conducted with the extracts of various plants, screening antimicrobial activity as well as for the discovery of new antimicrobial compounds [3,4,5,6]. More and more pharmacological studies have reported that the extract of T. catappa leaves and fruits have anticancer, antioxidant, anti-HIV reverse transcriptase, anti-inflammatory, antidiabetic effects and hepatoprotective activities [16,17,18,19] but the effective components and related mechanisms remain unknown. Antimicrobial activity of T. catappa leaf extracts were investigated against an array of clinically isolated as well as standard microbial cultures
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