Abstract
A novel disinfectant studied using an EPA protocol demonstrated sustained antimicrobial activity (ie, 3-5 log10 reduction) in 5 minutes after 24 hours for Staphylococcus aureus, vancomycin-resistant Enterococcus, Candida auris, carbapenem-resistant Escherichia coli and antibiotic-susceptible E. coli, and Enterobacter spp. Only ∼2 log10 reduction occurred with carbapenem-resistant Enterobacter spp and K. pneumoniae, and antibiotic-susceptible K. pneumoniae.
Highlights
Environmental contamination plays an important role in the transmission of several key healthcare-associated pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), Clostridioides difficile, and Acinetobacter
Ample evidence supporting the role of the contaminated surface environment in the transmission of healthcare pathogens has been published: surfaces are frequently contaminated; pathogens survive for days to months; contact with surfaces results in hand and/or glove contamination; disinfection reduces surface and hand contamination via touch and healthcare-associated infections; rooms are inadequately cleaned and disinfected; patients admitted to a room previously occupied by a patient colonized or infected with a pathogen have an increased likelihood of developing colonization or infection with that pathogen, which can be reduced by improved terminal disinfection.[1,2]
We evaluated a novel disinfectant that is registered by the Environmental Protection Agency (EPA) to kill microbes on surfaces for at least 24 hours
Summary
Environmental contamination plays an important role in the transmission of several key healthcare-associated pathogens, including methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), Clostridioides difficile, and Acinetobacter. Ample evidence supporting the role of the contaminated surface environment in the transmission of healthcare pathogens has been published: surfaces are frequently contaminated; pathogens survive for days (eg, vegetative bacteria) to months (ie, C. difficile spores); contact with surfaces results in hand and/or glove contamination; disinfection reduces surface and hand contamination via touch and healthcare-associated infections; rooms are inadequately cleaned and disinfected; patients admitted to a room previously occupied by a patient colonized or infected with a pathogen (eg, MRSA, VRE, or C. difficile) have an increased likelihood of developing colonization or infection with that pathogen, which can be reduced by improved terminal disinfection (eg, ultraviolet irradiation [UV]).[1,2] a limitation of “no touch” technologies, such as UV, is that they can only be used for terminal room disinfection because they require removal of all persons from the room. The intent of routine (eg, daily) disinfection is to make surfaces and equipment hygienically clean (not sterile), that is, free of pathogens in sufficient numbers to prevent human disease.[2,3] If an antimicrobial residue remains on a disinfected surface and it persists on the surface for 24 hours, it could guard against recontamination with
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