Abstract
The global number of bees has recently declined. One reason is pathogenic microorganisms including Paenibacillus larvae, which causes American foulbrood disease, and Melissococcus plutonius, which causes European foulbrood disease. The aim of this study was to identify new antimicrobial agents against foulbrood disease. Broth-microdilution assays with 20 natural compounds were used to detect the in vitro antimicrobial activity against foulbrood disease, and MTT assays were performed to determine cytotoxicity against a human cell line. 4-Hydroxydericin, sophoraflavanone G, acetylshikonin, and kurarinone were found to have antimicrobial activity against P. larvae and M. plutonius, with less cytotoxicity against HaCaT cells. In addition, these compounds have a synergic effect with tetracycline or macelignan, which could potentially be effective to control foulbrood disease of honey bees.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
