Abstract
Sida L. is one of the most diverse genera within Malvaceae, with species popularly used in different countries for the treatment of diseases. Scientific support for the ethnopharmacological potential of some of these species has been provided by bio-assays. In this work, leaf extracts of S. galheirensis, one of the least chemically and pharmacologically studied species, were evaluated for antibacterial and antifungal activity and drug-modulatory potential. The chemical composition of the extracts was analyzed using liquid chromatography and mass spectrometry (UPLC–ESI–QTOF–MSE). Seven constituents belonging to the flavonoid and fatty acid classes were identified. The extracts did not show significant antibacterial activity, but the modulatory potential with the antibiotic ofloxacin was significant against one of the strains of Staphylococcus aureus, with a reduction in MIC of more than 50%. Antifungal activity of the ethanol extract was verified against one of the strains of Candida albicans. Sida galheirensis extracts also significantly potentiated the activity of fluconazole against strains of C. albicans and C. tropicalis. Our findings showed that S. galheirensis leaf extracts have active constituents that enhance antimicrobial activity when associated with standard drugs.
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