Antimicrobial Activity in the Gasphase with Hypochloric Acid

Abstract

Abstract Background:The study investigated if the disinfecting potential of Hypochlorous acid (HOCl) in suspensions are transferrable to in-air cleaning applications and to what extent aerosolized HOCl solutions can deactivate indoor microbial contaminations in-air at or below legal limits. Material and Method: For the liquid disinfection we used a standard suspension disinfection test protocol. For the in-air tests we conducted several experiments where aerosolized bacterial suspensions were injected into lab chambers preloaded with different HOCl gas concentrations. Results:In suspension experiments we found sufficient efficacies for all studied organisms at minimum concentrations of 200 ppm HOCl. The in-air measurement set-up allows to follow microbe deactivation by HOCl interaction. The deactivation rate increases with the HOCl concentration, and the values are highest for Gram-negative bacteria. Conclusion:We confirmed our hypothesis of the high disinfecting power of HOCl in-air at safe levels for populated indoor places. The investigated bacteria provide a model system for infectious particles, including enveloped viruses (to which Coronavirus belongs). These early results suggest that HOCl should be further evaluated as an air-cleaning method which may complement established concepts.