Abstract
The correlative antimicrobial analysis of amino acid Schiff base and derivatized tren metal complexes: A= [MLCl2], B= [ML(CH3OH)2], respectively, against fungal strains, Candida parapsilosis, Candida albicans, Candida krusei, and Cryptococcus neoformans and (Gram-negative) P. aeruginosa, E. coli, S. typhimurium, and S. pyogenes, Methicillin-resistant Staphylococcus aureus (MRSA), S. mutans (Gram-positive) bacterial strains had been done by disk diffusion method following McFarland protocol. [CuLCl2] and [Cu (CH3OH)2] manifest overwhelming activity against microbes than other metal complexes of cobalt, nickel and zinc. Minimum inhibition concentration data also shows that copper complexes have the lowest MIC values against these tested microorganisms. The significance of this investigation is to uncover shielding and constructive therapeutic agents that wield against bacterial and fungal infection.
Highlights
The correlative antimicrobial analysis of amino acid Schiff base and derivatized tren metal complexes: A= [MLCl2], B= [ML(CH3OH)2], respectively, against fungal strains, Candida parapsilosis, Candida albicans, Candida krusei, and Cryptococcus neoformans and (Gram-negative) P. aeruginosa, E. coli, S. typhimurium, and S. pyogenes, Methicillin-resistant Staphylococcus aureus (MRSA), S. mutans (Gram-positive) bacterial strains had been done by disk diffusion method following McFarland protocol. [CuLCl2] and [Cu (CH3OH)2] manifest overwhelming activity against microbes than other metal complexes of cobalt, nickel and zinc
We report the invitro antifungal and antibacterial activity of Schiff base metal complexes [A] derived from TREN [MLCl2] [M= Co2+, Ni2+, Cu2+, Zn2+] and Schiff base metal complex [B] derived from amino acids [ML(CH3OH)2]
All the metal complexes reveal antimicrobial activity, and they were found to be active inhibitors against bacterial strains. (Table1, 2) and fungal strains (Table 3, 4). Responsiveness of both the testing coordinated complexes A= [MLCl2] and B = [ML(CH3OH)2] (M= Co2+, Ni2+, Cu2+, Zn2+ ) was evaluated based on the diameter of the inhibition zone against Pseudomonas aeruginosa, Escherichia coli, Salmonella typhimurium, (Gram-negative) and Streptococcus pyogenes, Methicillin-resistant Staphylococcus aureus (MRSA), Streptococcus mutans (Grampositive) bacterial strains.The analysis of results presented in Tables 1 and 2 shows the antibacterial activities of four different metal-ligand complexes against the gram-negative and gram
Summary
The correlative antimicrobial analysis of amino acid Schiff base and derivatized tren metal complexes: A= [MLCl2], B= [ML(CH3OH)2], respectively, against fungal strains, Candida parapsilosis, Candida albicans, Candida krusei, and Cryptococcus neoformans and (Gram-negative) P. aeruginosa, E. coli, S. typhimurium, and S. pyogenes, Methicillin-resistant Staphylococcus aureus (MRSA), S. mutans (Gram-positive) bacterial strains had been done by disk diffusion method following McFarland protocol. [CuLCl2] and [Cu (CH3OH)2] manifest overwhelming activity against microbes than other metal complexes of cobalt, nickel and zinc. Owing to the presence of azomethine (-C=N-) functional group, it gets bonded with two or more biologically active heterocyclic or aromatic compounds to form various types of molecular hybrids possessing excellent antimicrobial properties. These Schiff bases are chelating agents that generally coordinate with metals, especially with d-block metals and lanthanides, and form stable chelates with vast therapeutic applications. Metal complexes, derived from halogenated salicylaldehyde, have enormous applications in a diverse field of study related to luminescent probes, anti-HIV antimicrobial, antitumor, bio-catalysts in DNA and RNA cleavage reactions due to the excellent coordination with metal ions These derivatized complexes are used as fungicides, insecticides, flavoring agents for the bouquet and liquor . The antimicrobial impregnated disk is placed on an agar medium previously inoculated with the test microorganism that picks up the moisture, and the antibiotic diffuses radially through the agar medium producing an antibiotic concentration gradient
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