Antimelanoma and Antityrosinase fromAlpinia galangalConstituents

Chih-Yu Lo,Zhi-Hong Wen,Li-Ching Lin,Yen-Ting Chen,You-Cheng Hseu,Hui-Min Wang,Po-Len Liu

doi:10.1155/2013/186505

Abstract

Two compounds, 1,7-bis(4-hydroxyphenyl)-1,4,6-heptatrien-3-one (BHPHTO) and bisdemethoxycurcumin (BDMC) they have been isolated from the rhizomes of Alpinia galangal, and the structures of both pure constituents were determined using spectroscopic analyses. The study examined the bioeffectivenesses of the two compounds on the human melanoma A2058 and showed that significantly inhibited the proliferation of melanoma cells in the cell viability assay. This research was also taken on the tests to B16-F10 cell line and showed minor inhibitory consequences of cellular tyrosinase activities and melanin contents. Our results revealed the anticancer effects of A. galangal compounds, and therefore, the target compounds could be potentially applied in the therapeutic application and the food industry.

Highlights

Alpinia galangal belongs to the Zingiberaceae family, and the herb grows mainly in South East Asia
Many essential oils were obtained by hydrodistillation
Only some studies for A. galangal grown in Taiwan were published [6]

Summary

Introduction

Alpinia galangal belongs to the Zingiberaceae family, and the herb grows mainly in South East Asia. For A. galangal rhizome chemical studies, a group of related phenylpropanoids was identified [4, 5]. The tubes that contained major components were concentrated and followed by eluting isocratically in the self-pack C18 with 80% methanol solution to obtain BHPHTO and BDMC. The human skin cancer A2058 cell lines were derived and purchased from the Bioresource Collection and Research Center (BCRC number: 60240, Hsinchu, Taiwan, ROC) the American Type Culture Collection (ATCC number: CRL-11147, Manassas, VA, USA).

Results

Conclusion