Abstract
In this study, the anti-melanogenic effects of Impatiens textori methanol extract (ITME) were evaluated. Using a cytotoxicity test, we determined that the maximum permissible level of ITME application to melan-a cells was over 200 μg/mL. ITME decreased melanin synthesis and melanocyte dendricity in a dose-dependent manner. When compared to a control, ITME treatment at 100 μg/mL significantly decreased melanin content and intracellular tyrosinase activity by 19.1% (p<0.05) and 8.4% (p<0.01), respectively. Treatment with 100 μg/mL of ITME significantly decreased tyrosinase mRNA and protein expression by 17.2% (p<0.05) and 22.0% (p<0.01), respectively. These results suggest that ITME has a fairly good skin-whitening activity in melan-a cells via inhibition of tyrosinase at the transcriptional level.
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