Abstract
<p class="Abstract">The aim of this study was to assess the antimalarial activity of nine medicinal plants used by Karens of Andaman and Nicobar Islands, against <em>Plasmodium falciparum</em> chloroquine-sensitive MRC-2 isolate. The methanol extracts were obtained by cold percolation method and<em> in vitro</em> antimalarial activity was assessed using M-III method. The results indicated that out of nine plant species tested, four plants, viz., <em>Z. spectabilis, S. wallichiana, C. pulcherrima</em> and <em>Amomum</em> sp. demonstrated significant antimalarial activity (50% inhibitory concentration values were 5.5 ± 0.7, 12.0 ± 2.5, 14.6 ± 1.3 and 37.3 ± 2.5 μg/mL respectively) with no toxicity effect on erythrocytes.</p><p> </p>
Highlights
Andaman and Nicobar Islands, a union territory of India, has been historically known for high malaria transmission
Antimalarial activity of ethnomedicinal plant used by Karens of Andaman and Nicobar Islands
The leaf extract of Z. spectabilis (IC50 5.5 ± 0.7 μg/mL) showed excellent antimalarial activity followed by extracts of S. wallichiana (IC50 12.0 ± 2.5 μg/mL), C. pulcherrima (IC50 14.6 ± 1.3 μg/mL) and Amomum sp. (IC50 37.3 ± 2.5 μg/mL)
Summary
Andaman and Nicobar Islands, a union territory of India, has been historically known for high malaria transmission. The tropical climate prevailing throughout the year provides an ideal environment for mosquito proliferation and breeding in Nicobar group of islands (Manimunda et al, 2011). Karen derives from the word ‘Kavin’ as British called them, while they called themselves as Pwakanyaw, the quiet and easy going people, hailing from Henzada, Pathe and Nachaon areas of Pegu district in Western Myanmar (Oberai, 2000). They inhabit three villages depending on agriculture and fishing for livelihood. As a part of the ongoing studies documented their traditional treatment practices and collected plants which were reported to be efficacious in the treatment of traditional medicine system
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
