Abstract
Investigation of the terrestrial Streptomyces sp. BCC27095 led to the isolation of two new (1 and 2) and two known (3 and 5) anthraquinone derivatives along with the previously reported compound, steffimycin B (4). The chemical structures were determined on the basis of NMR spectroscopic data. These compounds exhibited significant antimalarial (against Plasmodium falciparum, K-1 multidrug resistant strain) and antimycobacterial (against Mycobacterium tuberculosis H37Ra) activities with IC50 values in the range of 0.32–3.20μg/mL and MIC in a range of 0.0031–1.56μg/mL, respectively. They were also evaluated for antibacterial activity against Bacillus cereus and for cytotoxicity against both malignant (MCF-7, KB, NCI-H187) and non-malignant (Vero) cells.
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