Abstract
AbstractPreparations from the roots of the Thai medicinal plant, Tiliacora triandra Diels, were found to have antimalarial activity against Plasmodium fakiparum in vitro. Methanol extraction yielded two alkaloidal components (water‐soluble and water‐insoluble). Only the water‐insoluble alkaloidal component showed an increase in antimalarial activity. From this component, five different alkaloids of the bisbenzyl‐isoquinoline group were isolated and identified as tiliacorine, tiliacorinine, nor‐tiliacorinine A, and two uncharacterized alkaloids G and H. Alkaloid G was found to be the most active in vitro schizontocide (ID50, 344 ng/mL) followed by nor‐tiliacorinine A and tiliacorine (ID50, 558 and 675 ng/mL, respectively).
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