Abstract
This work was done to identify some of the plants used in the treatment of malaria in Uganda and to investigate their efficacy in the in-vitro assays. Plumbago zeylenica and Cryptolepis sanguinolenta showed marked activity on the chloroquine resistant and chloroquine sensitive strains of Plasmodium falciparum . Plumbagin, a quinone, was isolated from Plumbago zeylenica , and found to have antimalarial activity with IC 50 of 178 ng/ml on chloroquine sensitive and 188 ng/ml on chloroquine resistant strains. Cytotoxicity assays on KB cell lines indicated that the extract was selective for Plasmodium falciparum . The Selective Index was 5 in both strains of Plasmodium falciparum . It was concluded that some of the plants used for malaria contain compounds with antimalarial activity, which can be useful leads for the development of new antimalarial drugs. Key Words: Antimalarial activity, Plumbago zeylenica, Cryptolepis sanguinolenta , plumbagin East and Central African Journal of Pharmaceutical Sciences Vol.5(2) 2002: 33-37
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