Abstract
This review of the literature relating to anti-lymphocyte sera (ALS) is discussed under the following headings:HistoricalPreparation of ALS-Species for production of ALS. Antigen. Immunization schedule. Treatment of ALS before use.In vitro properties of ALS-Effects on lymphocytes. Antibody specificity (tissue antigen specificity, species and strain specificity). Characterization of ALS antibodies.In vivo properties of ALS-Haematological effects. Histopathological effects. In vivo localization of ALS. Immunosuppressive activity of ALS (prolongation of homograft survival; humoral antibody formation; hypersensitivity, disordered immune responses and inflammation; auto-immune disease; tumour growth and transplantation; viral and other infections; graft-versus-host reaction; lymphocyte transfer reactions; complications of ALS treatment).Correlation of in vitro and in vivo properties of ALSPotentiation of the in vivo effects of ALSMechanism of action of ALS-Cytotoxic theory. Competitive antigen theory. Blindfol...
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