Abstract
The effects of intra-arterial infusions of digoxin 0.1 μg/min for 30 min on metabolism of the perfused forearm were studied. Infusion of digoxin in 4 subjects did not significantly alter forearm blood flow, oxygen consumption, vascular resistance, lactate production or arterio-venous differences for free fatty acids; however, glucose uptake was significantly increased. Infusion of epinephrine 0.1 μg/mg for 45 min in 4 subjects increased forearm blood flow, reduced forearm vascular resistance and significantly increased lactate production from forearm muscle and free-fatty acid loss from forearm adipose tissue. Infusion of epinephrine 0.1 μg/min for 45 min in 4 subjects after the 30-min infusion of digoxin resulted in similar increases in forearm blood flow and lactate production as with the epinephrine infusions alone; however, arterio-venous differences for free fatty acids were significantly reduced. Prior infusion of digoxin also inhibited the lipolysis but not the glycolysis associated with epinephrin...
Published Version
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