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Abstract
In order to estimate anti-leukocidin antibody in sera of patients, an ELISA test using horseradish peroxidase conjugated protein A was devised.Sera of 39 cases of diffuse panbronchiolitis (DPB) were investigated for anti-leukocidin antibody.Mean antibody anti-leukocidin titer in sera of 17 DPB cases which had not been infected with Pseudomonas aeruginosa and 5 DPB cases which were transiently infected with the bacteria, were not significantly different from the mean anti-leukocidin titer in sera of 11 healthy control cases, while the mean anti-leukocidin titer in sera of 17 DPB cases persistently colonized was significantly higher than in the former cases.These results indicate that leukocidin was produced at the local site of infection in DPB patients. Studies to clrify the role of leukocidin in the pathogenicity of DPB are needed.
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Schedule a callMore From: Kansenshogaku zasshi. The Journal of the Japanese Association for Infectious Diseases
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