Abstract
Melodinus eugeniifolus, a very rare medical plant which belongs to the family of Apocynaceae, has just been discovered in the Malaysia rain forest. Six different extracts of Melodinus eugeniifolus (a very rare medical plant belongs to Apocynaceae) leaves and barks were screened for the in vitro antileishmanial and antibacterial activities, among the different extracts tested, the ethanol and hexane extract of barks showed significant antileishmanial activities with IC50 value of 159.9 μg/ml and 270.3 μg/ml. All the extracts displayed remarkable antibacterial activity against Staphylococcus aureus, Bacillus cereus and Escherichia coli. Highlights: Melodinus eugeniifolus, a very rare medical plant from South Asian rain forest which may be a potential drug for many diseases is first reported its antileishmanial and antimicrobial activities.
Highlights
IntroductionAntimicrobials (antibiotics) have played an essential role in decreasing morbidity due to infectious diseases
Antimicrobials have played an essential role in decreasing morbidity due to infectious diseases
The following bacterial strains were employed in the screening: Gram-positive bacteria such as Staphylococcus aureus (ATCC 11632), Bacillus cereus (ATCC 10876), methicillin-resistant Staphylococcus aureus (ATCC 43300) and Gram-negative bacteria such as Escherichia coli (ATCC 10536) and Pseudomonas aeruginosa (ATCC 10145)
Summary
Antimicrobials (antibiotics) have played an essential role in decreasing morbidity due to infectious diseases. Antimicrobials are used for treatment of infections and for prophylaxis against infections in humans and animals, for growth promotion in food animal rearing and in agriculture. Infectious diseases remain as the leading cause of death worldwide and bacteria has become more resistant to conventional antibiotic in recent years. The widespread use of these compounds is thought to further encourage the emergence of antimicrobial resistance [1]. The number of resistant pathogenic bacteria grows at an alarming rate worldwide and the search. (2014) Antileishmanial Assay and Antimicrobial Activity on Crude Extracts of Melodinus eugeniifolus Barks and Leaves from Malaysia.
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