ANTIINFLAMMATORY PROPERTIES OF PEPTIDE COMPLEX OBTAINED FROM THE COD LIVER (GADIDAE) ON THE MODEL OF ADJUVANT ARTHRITIS IN THE RAT

Abstract

s. PHYTOPHARM 2012 M 94 Obzory po kliniceskoj farmacologii i lekarstvennoj terapii [Reviews of clinical pharmacology and drug therapy] ТОМ 10/2012/2 exist due to relatively high content of ferulic acid in sugar beet fibres (Table 1). Most of the phenolic substances in the additives were found in nonextractable fractions, which have been shown to possess significantly higher antioxidant activity than extractable fractions (Table 2). The obtained results suggest the possibility for upgrading the functionality of meat products with incorporated NTf and Tf additives, which is in line with the basic concept of ChANCE. RESEARCHES ON TANNINS CONTAINING MEDICINAL VEGETATIVE RAW MATERIALS STANDARDIZATION © Samylina I. A., Grinko E. N. Table 2. Antioxidant activity of extractable and nonextractable fractions, expressed as iC 50 (g sample/ml), (M ± m) CAf Tf NTR dPPh activity of extractable fraction 0.89 ± 0.11 1.93 ± 0.52 1.12 ± 0.18 dPPh activity of nonextractable fraction 0.02 ± 0.01 0.14 ± 0.01 0.07 ± 0.01 AOA activity of extractable fraction 2.45 ± 0.15 4.84 ± 0.69 3.21 ± 0.36 AOA activity of nonextractable fraction 0.80 ± 0.32 0.59 ± 0.06 0.34 ± 0.07 Reducing activity of extractable fraction 0.27 ± 0.01 1.01 ± 0.06 0.48 ± 0.01 Reducing activity of nonextractable fraction 0.03 ± 0.01 0.13 ± 0.01 0.06 ± 0.01 Chelating activity of extractable fraction 0.22 ± 0.07 0.47 ± 0.20 1.24 ± 0.19 Chelating activity of nonextractable fraction 0.29 ± 0.05 0.18 ± 0.06 1.13 ± 0.09 Means in each row followed by the same superscript are not significantly different, P < 0.05 First Moscow State Medical University I. M. Sechenov, Moscow, Russia Objective of the study was standartisation of medicinal vegetative raw material (MVRM) containing tannins. The objects of research were oak and viburnum bark; bistort, bergenia, tormentil and sanguisorba rhizomes; bilberry, bird cherry and alder fruit; sumag and smoke tree leaf. The microscopic, chromotographic, UV-, infraredand Raman-spectro-scopic characteristics of plant material were done. Tannins were determined by hPlC, UV-spectroscopy, potentiometric titration. The possibility of collagen 1 % solutions application as a tannins sedimentation reagent was investigated. The quantitative method of the tannins definition in plants material was developed and patented. UV-, infraredand Raman-spectroscopic characteristics for 11 types of MVRM and 8 standard samples (glucose, starch, fructose, tannin, pyrogallol, gallic and ellagic acids, rutine) were recorded and described. The spectra are recommended for identification of powders of raw materials. We’ve studied the diagnostic signs variability of MVRM at crushing. The anatomic and diagnostic signs of crushed and powdered raw materials were specified. The most variability elements (bunches and their parts, mechanical fibers, the oxalate calcium crystals chains; conglomerates of stony cages and fibers) were revealed and described: and also the signs, allowing to identify powders of similar types of raw materials.