Abstract
A new lignan, named acanthosessilin A (1), as well as eight known lignan and lignan glycosides 2−9 were isolated from an ethanolic extract of Acanthopanax sessiliflorus fruits. The chemical structures were determined by spectroscopic methods, including HR-EIMS, 1D NMR (1H, 13C, DEPT), 2D NMR (gCOSY, gHSQC, gHMBC, NOESY), and IR spectroscopy. All isolated compounds were tested for the ability to inhibit LPS-induced nitric oxide production in RAW264.7 macrophages.
Highlights
Acanthopanax sessiliflorus (Rupr. et Maxim) Seem, belonging to the Araliaceae family, is widely distributed in Korea, China, and Japan
A 70% ethanolic extract of dried A. sessiliflorus fruits was suspended in H2O and extracted with
The amount of nitric oxide (NO) was determined by the nitrite concentration in cultured RAW264.7 macrophage supernatants using the Griess reagent
Summary
Acanthopanax sessiliflorus (Rupr. et Maxim) Seem, belonging to the Araliaceae family, is widely distributed in Korea, China, and Japan. The bark and twigs of Acanthopanax species are traditionally used in Korea as anti-rheumatoid arthritis, anti-inflammatory, and anti-diabetic drugs and are recognized to have ginseng-like activities [1,2]. Previous studies on its phytochemicals resulted in the isolation of lignans from the leaves and roots of Acanthopanax species [3,4,5], and eleutheroside E has been identified as a major compound in the fruits of Acanthopanax species [6]. Most phytochemical and pharmacological studies have mainly focused on the leaves, bark, and roots of Acanthopanax species, and only a few reports have investigated the fruits. Several previous studies have provided evidence for the anti-inflammatory effects of extracts and components from Acanthopanax species [10,11,12]. Isolated compounds 1 9 were evaluated for anti-inflammatory activities through the measurement of nitrite, a soluble oxidation product of nitric oxide (NO), in lipopolysaccharide (LPS)-induced RAW 254.7 macrophage cells
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