Abstract
The stalks of Polygonum hydropiper L. (PHL) have been traditionally used in clinical practice for thousands of years in China to treat various inflammatory diseases. However, little research has been conducted to investigate the anti-inflammatory effects of PHL on TNBS-induced intestinal inflammation in rats. The aim of the present study was to investigate the anti-inflammatory effects and to explain the underlying mechanism of PHL on TNBS-induced intestinal inflammation in rats. PHL (125, 250, and 500 mg/kg) was given for 7 consecutive days to rats with intestinal inflammation induced by TNBS. Oral administration of an aqueous extract of a high dose of PHL (H-PHL) significantly improved TNBS-induced symptoms such as the macroscopic score and histological examination. H-PHL treatment significantly ameliorated the activity of MPO and improved the GSH content. In addition, there was a downregulation of the TNBS-induced increase in the activity of iNOS and levels of Cox-2, TNF-α, and IL-1β while the protein expression of NF-κB was significantly unregulated after administration of H-PHL. The present findings suggested that H-PHL has a protective effect on experimental intestinal inflammation in rats and its anti-inflammatory effects are closely related to inhibition of NF-κB signal pathways.
Highlights
Inflammatory bowel disease (IBD) is a chronic digestive tract disease, mainly Crohn’s disease and ulcerative colitis (UC), which is characterized by continuous or recurrent diffuse inflammation of the colon mucosa, and submucosa, and its clinical manifestations are diarrhea, blood in the stool, and abdominal pain [1, 2]
The TNBS control had a significantly shorter colon length compared with the nonintestinal inflammation (NII) control
It is well known that the first-line chemical and biological options widely used in the treatment of IBD have a significant effect, their severe side effects, especially the high palindromic rate of these therapies, have caused much concern
Summary
Inflammatory bowel disease (IBD) is a chronic digestive tract disease, mainly Crohn’s disease and ulcerative colitis (UC), which is characterized by continuous or recurrent diffuse inflammation of the colon mucosa, and submucosa, and its clinical manifestations are diarrhea, blood in the stool, and abdominal pain [1, 2]. Several investigations have demonstrated the efficacy of these treatments which have made a substantial contribution to the treatment of the disease. These drugs have many serious side effects and there is a high recurrence of IBD, and no definitive therapies are available for this disorder [5, 6]. (PHL), commonly used as a traditional Chinese medicine, have been widely used in the treatment of inflammatory diseases. The compounds present in PHL have been reported to Mediators of Inflammation have multiple effects and involve antifungal agents (polygodial and warburganal), anti-inflammatory agents (polygonolide), and antioxidants (hydropiperoside, rhamnazin, persicarin) [10,11,12,13,14]. The PHL methanol extract has a potential anti-inflammatory effect [16]. The mechanism involved in the protective effect against intestinal inflammation remains unknown
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
