Anti-inflammatory effect of vitamin D3 on chronic gingivitis

Abstract

Aims: To investigate the effects of vitamin D3 on chronic gingivitis and to evaluate its effect on Tumor necrosis factor-α and Interleukin-6 in their saliva. Material and Method: Forty patients were classified into two groups: - group 1: (20) chronic gingivitis patients, did not receive any medication (control group), group 2: (20) chronic gingivitis patients (treatment group), received Vitamin D3 1000IU capsule/ day. Scaling and polishing have been carried out for each volunteer to reach the base line for gingival index, oral hygiene index and calculus index. Then these indices were measured for all patients on the next day, after 3 weeks and after 6 weeks in both groups. Five milliliters of unstimulated saliva were collected for measurement of human salivary Tumor necrosis factor-α and Interleukin-6 by ELISA Kits. Results: significant differences were observed between treatment and control groups throughout study days with significant reduction in oral health indices in 21st and 42nd days of treatment group. Comparisons between the salivary parameters showed significant decreases in Tumor necrosis factor-α and Interleukin-6 levels throughout 1st, 21st and 42nd day in treatment group, while in control group no significant differences were observed for IL-6 but significant increase in levels of TNF α was detected. Conclusion: Vitamin D3 has beneficial effect during treatment of chronic gingivitis.