Abstract
Complexes of Zn(II), Cd(II) and Pt(II) metal ions with the anti-inflammatory drugs, 1-methyl-5-( p-toluoyl)-1H-pyrrole-2-acetic acid (Tolmetin), α-methyl-4-(2-methylpropyl)benzeneacetic acid (Ibuprofen), 6-methoxy- α-methylnaphthalene-2-acetic acid (Naproxen) and 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-1H-indole-3-acetic acid (indomethacin) have been synthesized and characterized. In the structurally characterized Cd(naproxen) 2 complex the anti-inflammatory drug acts as bidentate chelate ligand co-ordinatively bound to metal ions through the deprotonated carboxylate group. Crystal data for 1: [C 32H 26O 8Cd], orthorhombic, space group P22 12 1, a=5.693(2) (Å), b=8.760(3) (Å), c=30.74(1) (Å), V=1533(1) Å 3, Z=2. Antibacterial and growth inhibitory activity is higher than that of the parent ligands or the platinum(II) diamine compounds.
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