Abstract
Pharmacological Study of a Siddha Holistic Herb Sivakaranthai - Sphaeranthus Amaranthoides Burm for Analgesic and Anti-Inflammatory activitiesV. Thanigavelan, V.Lakshmanakumar, V.Kaliyamurthi, M. Pitchiah Kumar, G. Victor Rajamanickam
Highlights
Inflammation is described as cellular events in response to infection and tissue injury
Inflammatory responses include enhanced vascular permeability and blood supply as well as increased migration of immune cells at damaged site (Yoon et al, 2009). It is characterized by the abundant production of nitric oxide (NO), prostaglandin (PG) E2, and cytokines such as tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6)
The inhibition effect of samples on TNF-α and IL-6 production in LPS-treated RAW 264.7 cells was determined by an enzyme-linked immunosorbent assay (ELISA) kit, as described in the manufacturer’s instructions
Summary
Inflammation is described as cellular events in response to infection and tissue injury. Upon anti-inflammatory screenings, ethyl acetate fraction exhibited good nitric oxide production inhibitory activity in lipopolysaccharide-induced RAW 264.7 cells. The isolates 2, 3 and 4 showed considerable inhibition on the production of nitric oxide in the RAW 264.7 cell without causing cell toxicities. Compounds 3 and 4 reduced the production of interleukin-6, an inflammatory cytokine, in dose-dependent manner in RAW 264.7 cells.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
