Abstract
Pharmacological Study of a Siddha Holistic Herb Sivakaranthai - Sphaeranthus Amaranthoides Burm for Analgesic and Anti-Inflammatory activitiesV. Thanigavelan, V.Lakshmanakumar, V.Kaliyamurthi, M. Pitchiah Kumar, G. Victor Rajamanickam
Highlights
Inflammation is described as cellular events in response to infection and tissue injury
Inflammatory responses include enhanced vascular permeability and blood supply as well as increased migration of immune cells at damaged site (Yoon et al, 2009). It is characterized by the abundant production of nitric oxide (NO), prostaglandin (PG) E2, and cytokines such as tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6)
The inhibition effect of samples on TNF-α and IL-6 production in LPS-treated RAW 264.7 cells was determined by an enzyme-linked immunosorbent assay (ELISA) kit, as described in the manufacturer’s instructions
Summary
Inflammation is described as cellular events in response to infection and tissue injury. Upon anti-inflammatory screenings, ethyl acetate fraction exhibited good nitric oxide production inhibitory activity in lipopolysaccharide-induced RAW 264.7 cells. The isolates 2, 3 and 4 showed considerable inhibition on the production of nitric oxide in the RAW 264.7 cell without causing cell toxicities. Compounds 3 and 4 reduced the production of interleukin-6, an inflammatory cytokine, in dose-dependent manner in RAW 264.7 cells.
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