Abstract
Anti-inflammatory and antioxidant property of curcumin were indicated in previous studies. In the present study, anti-inflammatory, antioxidant and immunomodulatory effects of curcumin in sensitized rat were evaluated. Control (C), ovalbumin sensitized (S), S treated with curcumin (Cu, 0.15, 0.30, and 0.60 mg/mL) and dexamethasone (1.25 μg/mL, S+D) were studied. Curcumin and dexamethasone were prescribed in animals’ drinking water during sensitization period. Total and differential WBC count, concentrations of PLA2, TP, IFN-γ, IL-4, IgE, oxidant and antioxidant in bronchoalveolar lavage fluid (BALF) were investigated. Total WBC, neutrophil and eosinophil counts, the levels of PLA2, TP, IgE, IL-4, NO2, NO3, and MDA in BALF were increased but lymphocyte percentage, SOD, CAT, thiol, IFN-γ levels and IFN-γ/IL-4 ratio decreased in S animals compared to controls (p
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