Abstract
Sesame oil (SO) is a supplement that has been known to have anti-inflammatory and antioxidant properties, which makes it effective for reducing atherosclerosis and the risk of cardiovascular disease. Due to the side effects of statins, the current recommended treatment for atherosclerosis and cardiovascular diseases, the idea of using dietary and nutritional supplementation has been explored. The benefits of a dietary health regime have piqued curiosity because many different cultures have reaped health benefits through the ingredients in their cooking with negligible side effects. The purpose of this literary review is to provide a broad overview of the potential benefits and risks of SO on the development of atherosclerosis and its direction toward human clinical use. Current in vivo and in vitro research has shed light on the effects of SO and its research has shown that SO can decrease low-density lipoprotein (LDL) levels while maintaining high-density lipoprotein (HDL) levels. Current limitations in recent studies include no standardized doses of SO given to subjects and unknown specific mechanisms of the different components of SO. Future studies should explore possible synergistic and adverse effects of SO when combined with current recommended pharmaceutical therapies and other adjunct treatments.
Highlights
BackgroundAtherosclerosis, the formation of plaques in arteries, has been the topic of extensive research due to its critical role in increasing the risk of cardiovascular diseases such as coronary heart disease (CHD) [1,2]
Studies have come up with two prominent hallmarks of pathogenesis: the accumulation of cholesterol in the endothelial lining of arteries carried by low-density lipoproteins (LDLs) and chronic inflammation due to a high ratio of prooxidants to antioxidants [2,3]
Studies have implied that these hallmarks of atherosclerosis are not independent but are part of the same process where the abnormal deposition of LDLcholesterol (LDL-C) leads to an inflammatory response resulting in fatty plaques and vascular occlusion [4,5]
Summary
Atherosclerosis, the formation of plaques in arteries, has been the topic of extensive research due to its critical role in increasing the risk of cardiovascular diseases such as coronary heart disease (CHD) [1,2]. Due to the high prevalence rate of one in four deaths due to CHD [1], many research studies have explored the mechanism of atherosclerotic plaque formation. Studies have implied that these hallmarks of atherosclerosis are not independent but are part of the same process where the abnormal deposition of LDLcholesterol (LDL-C) leads to an inflammatory response resulting in fatty plaques and vascular occlusion [4,5].
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
