Abstract
The effect of petroleum ether fraction (50 and 100 mg/kg) and ethyl acetate fraction (50 and 100 mg/kg) of Tamarindus indica Linn. (Leguminosae) seeds was investigated in various experimental models of pain and inflammation. Anti-inflammatory activity of petroleum ether fraction and ethyl acetate fraction was studied using carrageenan induced paw edema and cotton pellet induced granuloma models in rats. Analgesic activity was studied in mice using tail immersion and hot plate models. Both petroleum ether fraction and ethyl acetate fraction significantly (P < 0.01) inhibited carrageenan induced paw edema and granuloma formation in cotton pellet induced granuloma model. Petroleum ether fraction and ethyl acetate fraction significantly (P < 0.01) increased latency to flick tail in tail immersion method and elevated the mean basal reaction time in hot plate method. Phytochemical analysis of petroleum ether fraction showed presence of steroids and ethyl acetate fraction showed presence of flavonoids and tannins. The ethyl acetate fraction was found to be more effective than petroleum ether fraction. Thus the anti-inflammatory and analgesic potential of T. indica seeds may be due to presence of active constituents like flavonoids and tannins present in ethyl acetate fraction.
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