Abstract
Attenuation of the chronic inflammatory response is a beneficial strategy to combat several human diseases. Traditional medicine offers many plant extracts and pure natural compounds as treatment options of a wide variety of disorders including acute and chronic inflammation. The present study was designed to evaluate the anti-inflammatory effect of silibinin in experimental animal models of chronic and granulomatous inflammations. Forty-eight rats were used to induce chronic inflammation in the hind paw with formalin and granulomatous inflammation with sterile cotton pellets. The anti-inflammatory activity of silibinin (300 mg/kg, P.O) was evaluated in the two models, and compared with that produced by dexamethasone (1 mg/kg, P.O). Silibinin decreased significantly the formation of exudate and granulation tissue compared with the vehicle, but still significantly lower than that produced by dexamethasone. In conclusion, our data suggest that silibinin inhibits the production of edema and granulation tissue in experimental animal models of chronic inflammation, and could be a potential choice for the treatment of chronic inflammatory disorders.
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