Anti-inflammatory Activity of Root of Dalbergia sissoo (Rox.b) in Carrageenan-Induced Paw Edema in Rats

Abstract

Dalbergia sissoo Roxb commonly known as Indian rosewood found throughout India, Bangladesh, Pakistan and Nepal up to 900 m. The root of Dalbergia sissoo Roxb was collected and then dried. The phytochemical analysis of hexane, chloroform and methanol extract revels presence of different phytochemical constituent's. The methanolic extract showed the presence of Alkaloids, Carbohydrates, saponins, flavonoids, glycosides (Cardiac glycosides, anthraquinone glycoside and saponin glycosides) and steroids.The methanolic extract of Dalbergia sissoo Roxb was investigated for anti-inflammatory activity in experimental animal models. Treatment with 70% methanolic extracts of Dalbergia sissoo demonstrate a diminished inflammation in rat hind paw when challenged with carrageenan induced paw edema. The methanolic extract of Dalbergia sissoo root at 1000 mg/kg showed the most potent anti-inflammatory activity compared to the other groups (100 and 500 mg/kg) throughout the observation period. Dalbergia sissoo Roxb was devoid of ulcerogenic effect on the gastric mucosa of rats in acute and chronic tests. It was concluded that the Dalbergia sissoo root extract possessed significant anti-inflammatory activity without any side effect on gastric mucosa.