Abstract
We investigated the anti-inflammatory activity of Senecio salignus. This medicinal plant is often used in Mexico for the treatment of fever and rheumatism. Chloroform and methanol extracts of the plant were tested on 12-O-tetradecanoylphorbol-13-acetate- (TPA-) induced edema in mice ears. The methanol extract of the plant inhibited edema by 36 ± 4.4% compared with the control, while the chloroform extract exhibited an even greater level of inhibition (64.1%). The chloroform extract was then fractionated, and the composition of the active fraction was determined by GC-MS. The anti-inflammatory activity of this fraction was then tested on TPA-induced ear edema in mice, and we found that the active fraction could inhibit edema by 46.9%. The anti-inflammatory effect of the fraction was also tested on carrageenan-induced paw edema in rats at doses of 100 mg/kg; a 58.9 ± 2.8% reduction of the edema was observed 4 h after administration of carrageenan, and the effect was maintained for 5 h.
Highlights
Inflammatory diseases are a major cause of morbidity and mortality in the world. These diseases are mainly treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and steroidal drugs, which have proven effective but can have negative side effects
We investigated the anti-inflammatory activity of S. salignus and the composition of the active fraction of the plant
The chloroform extract was separated by column chromatography; the column was packed with silica gel (Kieselgel 60, 70–230 mesh ASTM), which was prepared using hexane as the mobile phase, and the polarity was increased with ethyl acetate
Summary
Inflammatory diseases are a major cause of morbidity and mortality in the world. These diseases are mainly treated with nonsteroidal anti-inflammatory drugs (NSAIDs) and steroidal drugs, which have proven effective but can have negative side effects. Ancient Mexican culture is rich in information on the plants used in traditional medicine, one of which is Senecio salignus. This plant is used to treat intermittent fevers and rheumatism, and in the state of Chiapas, it is used as an insecticide in corn stores and as an ornamental plant [3, 4]. We investigated the anti-inflammatory activity of S. salignus and the composition of the active fraction of the plant
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
