Anti-infective therapy of peri-implant mucositis with adjunctive delivery of a sodium hypochlorite gel: a 6-month randomized triple-blind controlled clinical trial.

Abstract

To evaluate the effects of adjunctive delivery of a sodium hypochlorite gel in the treatment of peri-implant mucositis (PM). Forty-six subjects with 68 implants diagnosed with PM were randomly assigned to two treatment groups. Prior to mechanical debridement, a sodium hypochlorite gel was delivered to the implants of the test group while implants of the control group received a placebo gel. Application of both test and placebo gels was repeated 5 times at baseline. The primary outcome variable was the change in pocket probing depth (PPD) between baseline and 6months. After 6months, the mean PPD decreased statistically significantly from 3.93 ± 1.09mm to 3.04 ± 0.46mm in the test (p = 0.0001) and from 3.68 ± 0.85mm to 3.07 ± 0.58mm in the control (p = 0.0001) group, respectively. No statistically significant difference (p = 0.53) was observed with respect to PPD changes from baseline to 6months between test (0.88 ± 1.04mm) and control group (0.61 ± 0.75mm), respectively. The number of implants with bleeding on probing (BoP) decreased statistically significantly from 33 to 18 in the test group (p = 0.0001) and from 34 to 23 in the control group (p = 0.0001) after 6months. In conclusion and within the limits of the present study, changes in PPD from baseline to 6months were not statistically significantly different between groups. Complete resolution of mucosal inflammation was not achieved with either of the therapies. The present outcomes have showed that a complete resolution of peri-implant mucositis is not possible to obtain by means mechanical debridement with or without a sodium hypochlorite gel application.