Abstract
Objective: Evaluation of the antitrypanosmal, antileishmanial, antimicrobial and antimalarial activities of the total ethanol extract and different fractions of Bignonia binata leaves. Method: The antitrypanosomal activity was evaluated in vitro on blood stage forms of Trypanosoma brucei and the antileishmanial activity was tested against Leishmania donovani. The antimicrobial effect was performed against Candida albicans ATCC 90028, Cryptococcus neoformans ATCC 90113 and Aspergillus fumigatus ATCC 90906,Staphylococcus aureus ATCC 43300 (MRS), Escherichia coli ATCC 35218, Pseudomonas aeruginosa ATCC 27853 and Mycobacterium intracellulare ATCC 23068. While, the antimalarial activity was examined onchloroquine-sensitive (D6, Sierra Leone) and the chloroquine-resistant (W2) strains of Plasmodium falciparum protozoan. Results: The ethyl acetate fraction exhibited 90% inhibition against Trypanosomabrucei, with IC50 value of 16.59 μg/mL. While,the aqueous fraction showed mild antimicrobial activity with inhibition 32% aginst Pseudomonas aerogenosa and 27% against methicillin resistance Staphylococcus aureus (MRS). On the other hand, all tested fractions showed no antimalarial activity at the tested concentration. Conclusion: The present study revealed the antitrypanosomal potency of B. binata leaves
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