Abstract
The idea of using anti-IgE antibodies as a potential therapy for allergic disease has previously been considered an attractive yet impossible approach. However, researchers from Genentech may have proved the seeptics wrong by developing a recombinant humanised anti-IgE monoclonal antibody, E25, that binds to and neutralises circulating IgE. Details of the clinical and preclinical experience with E25, as well as Genentech’s plans for further development with this agent, were presented at the International Symposium on Clinical Immunology [ San Francisco, US; July 1995 ].
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