Abstract
Evidence has recently accumulated showing that anti–idiotypic antibodies specific to anti–FVIII antibodies are present in the plasma of healthy individuals and of haemophilia A patients with or without inhibitors, where they can neutralise the FVIII inhibitory activity. Additionally, patients successfully desensitised towards FVIII have an increased production of anti–idiotypic antibodies with no significant reduction in anti–FVIII antibodies. We review here possible strategies for modulating the anti–FVIII immune response by idiotypic interactions.
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