Abstract
Ginseng possesses a wide spectrum of medicinal effects and has widely been used in traditional medicine for thousands of years. In this study, the antihypertensive effect of Korean wild simulated ginseng in spontaneously hypertensive rats was investigated. Three groups of hypertensive rats-a group without wild simulated ginseng treatment; another group treated with 100mg of wild simulated ginseng extract/kg of body weight; and the other group treated with 200mg of wild simulated ginseng extract/kg of body weight were tested over 8weeks. The two wild simulated ginseng-treated groups showed significantly (p < 0.05) reduced systolic blood pressure at 4 and 6weeks of wildsimulated ginseng treatment. However, the wild simulated ginseng treatment did not adversely affect the food intake, serum electrolytes, osmolality, heart weight, heart rate, and the cross-section of the aorta as well as enzyme activities. The results suggested that Korean wild simulatedginseng is effectively used for reducing high systolic blood pressure in hypertensive patients without causing adverse health effects.
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