Abstract
SummaryThe historical and molecular derivatives of thiazide and sulphonamide diuretics from 4-sulphonamido benzoic acid are briefly discussed. In a search for new antihypertensive agents many novel 3-sulphamoyl-4-chlorobenzamides in the indoline and iso-indoline series were synthesized. These compounds were screened in a battery of pharmacological tests and, in particular, their antihypertensive and diuretic activities were investigated in experimental hypertensive rats. The research programme resulted in the selection of indapamide as a compound which produced a significant and prolonged antihypertensive action with only a slight and transient diuresis.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
