Antihypertensive and Cardioprotective Property of Mimosa pudica Using Zebra Fish

Abstract

Pharmacognosy Research,2022,14,3,333-337.DOI:10.5530/pres.14.3.49Published:July 2022Type:Original ArticleAuthors:Santhosh Kondajji Hanumanthappa, Joy Hoskeri Harris, Nivedita Pujari Sudhakar, Priyanka Ashoka, and Manjunatha Hanumanthappa Author(s) affiliations:Santhosh Kondajji Hanumanthappa1, Joy Hoskeri Harris2, Nivedita Pujari Sudhakar2, Priyanka Ashoka1, Manjunatha Hanumanthappa1,3* 1Department of Biotechnology and Bioinformatics, Jnanasahyadri, Kuvempu University, Shankaraghatta, Shivamogga, Karnataka, INDIA. 2Department of Bioinformatics, Karnataka State Akkamahadevi Women’s University, Torvi, Vijayapura, Karnataka, INDIA. 3Department of Biochemistry, Jnana Bharathi Campus, Bangalore University, Bangalore, Karnataka, INDIA. Abstract:Background: Increase in blood pressure is generally termed as hypertension which is one of the common causes of cardiovascular diseases. Despite the several treatment methods, hypertension stands to be the major concern in developing countries. Angiotensin converting enzyme is one of the key contributors in regulating blood pressure where improper activation of angiotensisn leads to hypertension. Mimosa pudica plant has been reported to exhibit several therapeutic properties and thus the current study was focused on evaluating antihypertensive property of phytochemicals found in the Mimosa pudica extract. Materials and Methods: Methanol extract of Mimosa pudica was examined for presence of potential phytochemicals by GC-MS and molecular docking studies were carried out using Autodock 4.2. Results: 07 phytochemicals were identified in the methanol extract of Mimosa pudica. Further molecular docking studies against angiotensin converting enzyme (ACE) was carried out and among the list of test compounds 9,12-octadecadienoic acid showed least binding energy with -6.6 kJ. Conclusion: Compounds selected as phytochemicals of Mimosa pudica from methanol extract of Mimosa pudica, specially 9,12-octadecadienoic acid considered for further evaluation of antihypertensive and cardioprotective activity. Keywords:Angiotensin converting enzyme, Antihypertensive activity, Antihypertensive and cardioprotective activity, Methanol extract, Mimosa pudicaView:PDF (270.04 KB)