Abstract
The present study aims to evaluate the antihyperipidemic effects of mature coconut water (MCW), a natural nutritious beverage and its role in regulating lipid metabolism in experimental diabetes. The experimental animals were divided into four groups—normal control, MCW-alone-treated rats, diabetic control, and diabetic rats treated with MCW. Blood glucose, lipid profile, atherogenic index, phospholipids in various tissues, free fatty acids, activities of various lipogenic enzymes, 3-hydroxy-3-methylglutaryl-coenzyme A (HMG CoA) reductase in liver, lecithin–cholesterol acyl transferase (LACT) in plasma, and lipoprotein lipase (LPL) in heart were evaluated in all the experimental groups. The results indicate that in diabetic rats, MCW treatment reduced the blood glucose and lipid levels in blood and other tissues along with reduced activity of HMG CoA reductase and increased activity of LACT and LPL. In addition, levels of triglycerides, phospholipids, and free fatty acids in various tissues and atherogenic index were significantly lowered. In conclusion, MCW significantly reduced hyperlipidemia and regulated the defects in lipid metabolism in diabetic rats, indicating the therapeutic potential of MCW in diabetes and associated atherogenic complications.
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