Abstract
Solanum anguivi Lam. fruit is commonly used in folklore medicine for the management of various diseases including diabetes in Nigeria. The present study evaluates the antihyperlipidemic, antiperoxidative, and hypoglycemic activities of saponins from Solanum anguivi fruits in alloxan‐induced diabetes rats. Diabetic rats were treated with saponin (20 – 100 mg/kg) for 21 days. Results indicated that administration of saponins significantly reduced the elevated levels of glucose, decreased total cholesterol (TC), total triglycerides (TG), low density lipoprotein (LDL) and increased high density lipoprotein (HDL) in the serum towards normalcy when compared to the diabetic control (P< 0.05). In addition, saponins exhibited strong inhibition of lipid peroxidation and increased the levels of antioxidant enzymes (superoxide dismutase and catalase) in the serum, liver and pancreas when compared to the diabetic control (P< 0.05). Our results suggest that saponins from S. anguivi fruit can enhance the hypoglycemic, hypolipidemic and antioxidant properties in alloxan‐induced diabetic rats, and may have the potential to be used in the prevention or in the management of diabetes.Support or Funding InformationThis research received no specific grant from any funding agency in the public, commercial, or not‐for‐profit sectors
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
