Abstract
The current study was designed to evaluate the hypolipidemic and renopro-tective effects of methanolic extract of powdered Canscora decussata whole plant in the diabetic rabbits. Thirty rabbits were divided into five groups having 6 animals each including normal and diabetic controls groups, the remaining groups received methanolic extract in 400 and 600 mg/kg doses and another group got pioglitazone (3 mg/kg) for 30 days. Serum levels of triglycerides, total cholesterol, LDL-cholesterol, HDL-cholesterol, albumin, globulin and total proteins were estimated by using commercially available kits. The results showed that extract significantly (p<0.01) decreased the raised parameters including triglyceride, total cholesterol and LDL-cholesterol, atherogenic index, Coronary risk index up to normal values compared to diabetic rabbits. However, it significantly increased HDL-cholesterol, albumin, globulin and total protein levels. Therefore, it is suggested that methanolic extract of C. decussata exerts hypolipidemic and renoprotective effects in the alloxan-induced diabetic rabbits. DOI: http://dx.doi.org/10.3329/bjp.v8i3.15506 Bangladesh Journal of Pharmacology Vol.8(3) 2013 323-327
Highlights
Hypercholesterolemia and hypertriglyceridemia have been reported to occur in the diabetic rabbits (Maciejewski et al, 2001; Wojtowiczet et al, 2004)
The plant C. decussata was collected from a village of Lahore, Pakistan in the month of August 2010 and got identified by the taxonomist of University of Sargodha, Sargodha
Chemicals used in the study include triglyceride, total cholesterol, LDL-cholesterol and HDL-cholesterol kits by Fluitest, Germany; alloxan monohydrate by Research Organics, USA; Methanol by Merck Chemical Co., Germany; and Gum acacia by Uni -Chem, Germany, pioglitazone was a generous gift from Maan Gee distributors, Sargodha
Summary
Hypercholesterolemia and hypertriglyceridemia have been reported to occur in the diabetic rabbits (Maciejewski et al, 2001; Wojtowiczet et al, 2004). High density lipoproteins decrease in type 2 diabetic patients which lead to atheromatous disease (Rang et al, 2003). The development of diabetic nephropathy has been characterized by progressive increase in the excretion of protein, albumin leading to end stage renal failure (Alberti et al, 1997). Diabetic nephropathy has been considered a major cause of endstage renal disease in many developed countries (CDC, 2005). In developing countries like Pakistan, 80% of population depending on traditional medicine in primary health care (Grover and Yadav, 2004) because these drugs are of low cost and free from adverse effects (Akhtar et al, 2011). Ethnopharmacological and ethno botanical surveys indicate that more than 1200 plants are used worldwide in herbal medicine to treat diabetes (Ziyyat et al, 1997; El-Hilaly et al, 2003; Tahraoui et al, 2007). Among them Actinodaphne hookeri, Aegle marmelos, Bombax ceiba, Cajanus scarabaeoides, Eulophia herbacea, Gymnema lactiferum, Lagerstroemia speciosa, Mangifera indica, Meyna spinosa, Nigella sativa, Teucrium stocksianum Trichosanthes tricuspidata have shown antidiabetic effect in their scientifically designed studies (Prajapati et al, 2008; Ravi et al, 2009; Pattanayak et al, 2009; Tatiya et al, 2013; Bandara et al, 2009; Saha et al, 2009; Bhowmik et al, 2009; Sen et al, 2013; Khanam et al, 2009; Alamgeer et al, 2013; Bhavsar and Talele, 2013; Kulandaivel et al, 2013)
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