Abstract
Antihyperglycemic Effect of Silkworm Powder, Fibroin and Sericin from Three Thai Silkworm (Bombyx mori Linn.) in Streptozotocin-Induced Diabetic Rats
Highlights
The silkworm was domesticated from the wild silk moth, Bombyx mandarina
The results revealed that fasting plasma glucose level in 6th week of Nanglai fibroin, Nangnoi fibroin and Nangnoi sericin expressed a better reduction of fasting blood glucose level (FPG) in diabetic rats compared with diabetic control groups (p
Silkworm powders, fibroin and sericin of three races exhibited a therapeutic potential for the reduction plasma glucose level
Summary
The domesticated B. mori and the wild B. mandarina can still breed and sometimes produce hybrids.[1] Silkworms have been bred to produce raw silk in China for thousands of years from where it spread to Korea and Japan, and later to India and the West.[2] Mulberry silkworm (B. mori) has been reared for longtime in many regions of Thailand especially the Northeast.[3] Reports on the various pharmacological activities of the silkworm have been accumulated such as antioxidant,[4] anticancer,[5] antibacterial,[6] antiviral,[7] antihypertensive,[8] and hepatoprotective activities.[9]. The purposes of this study was to compare hypoglycemic activity of silkworm powder, fibroin and sericin from three Thai mulberry silkworm races as well as investigation of the hematological and biochemical parameters in STZ-induced diabetic rats after oral administration of silkworm powder (5th-instar, 3rd-day), fibroin, and sericin
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