Antihyperglycemic effect of ganoderma lucidum polysaccharides on streptozotocin-induced diabetic mice.

Fenglin Li,Zhijian Zhong,Yiming Zhang

doi:10.3390/ijms12096135

Abstract

The current study evaluated the glucose-lowering effect of ganoderma lucidum polysaccharides (Gl-PS) in streptozotocin (STZ)-induced diabetic mice. The diabetic mice were randomly divided into four groups (8 mice per group): diabetic control group, low-dose Gl-PS treated group (50 mg/kg, Gl-PS), high-dose Gl-PS treated group (150 mg/kg, Gl-PS) and positive drug control treated group (glibenclamide, 4 mg/kg), with normal mice used as the control group. Body weights, fasting blood glucose (FBG), serum insulin and blood lipid levels of mice were measured. After 28 days of treatment with Gl-PS, body weights and serum insulin levels of the Gl-PS treated groups was significantly higher than that of the diabetic control group, whereas FBG levels was significantly lower. Moreover, total cholesterol (TC), triglyceride (TG) and low density lipoprotein cholesterol (LDL-C) levels of the Gl-PS treated groups had dropped, whereas the high density lipoprotein cholesterol (HDL-C) levels had increased. In addition, according to acute toxicity studies, Gl-PS did not cause behavioral changes and any death of mice. These data suggest that Gl-PS has an antihyperglycemic effect. Furthermore, considering the Gl-PS effects on lipid profile, it may be a potential hypolipidaemic agent, which will be a great advantage in treating diabetic conditions associated with atherosclerosis or hyperlipidemia.

Highlights

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and alterations in carbohydrate, fat, and protein metabolism, associated with absolute or relative deficiencies in insulin secretion and/or insulin action
Type II diabetes accounts for about 90% of the disease, and is characterized by peripheral insulin resistance and impaired insulin secretion, which is often associated with lipid and lipoprotein disorders [6,7,8]
This study indicates that ganoderma lucidum polysaccharides (Gl-PS) have an antihyperglycemic effect

Summary

Introduction

Diabetes mellitus (DM) is a metabolic disorder characterized by hyperglycemia and alterations in carbohydrate, fat, and protein metabolism, associated with absolute or relative deficiencies in insulin secretion and/or insulin action. The number of adults with diabetes in the world will rise to 300 million by the year 2025 and the major part of this numerical increase will occur in developing countries [5]. Many oral hypoglycemic agents, such as biguanides, are available for the treatment of diabetes [9], but these synthetic agents are associated with drawbacks such as rigid and multiple dosing regimen, high-cost, inaccessibility and untoward effects [10]. These factors have contributed to the recent increase in the use of folkloric plant products

Objectives

Results

Conclusion