Abstract
ABSTRACT The present study was designed to investigate the antihyperglycemic activity of the aqueous extract of sea buckthorn (Hippophae rhamnoides L.) seed residues (ASSR) in streptozotocin (STZ) and high-fat diet (HFD)-induced type 2 diabetic rats. Male Sprague-Dawley rats were divided into a normal control group (control), diabetic group and diabetic group supplemented with ASSR. Type 2 diabetes was induced by intravenous injection of low-dose STZ (25 mg/kg b.w.) and feeding with HFD for 10 weeks. Vehicle (distilled water) and ASSR (400 mg/kg b.w.) were orally administered once a day for 6 weeks. Our results showed that administration of ASSR significantly lowered the body weight, serum glucose, total cholesterol and low-density lipoprotein cholesterol levels in diabetic rats. Meanwhile, ASSR also significantly increased insulin sensitivity index in diabetic rats. These results suggest that ASSR might exhibit hypoglycemic and hypolipidemic effects in the STZ–HFD-induced type 2 diabetic rats. PRACTICAL APPLICATIONS Sea buckthorn (Hippophae rhamnoides L.) bush, bearing delicious and nutritious orange-colored berries, is locally called “Shaji” in China. The berry of sea buckthorn is one of the edible crude herbs that have been in use in Tibetan and Mongolian traditional medicines for a long time. In addition to medicinal use, the berries are processed into various products such as juice and marmalade, and are used for flavoring of dairy products. As a part of sea buckthorn berry, its seed is a by-product of the berry processing industry and also contains many bioactive substances. It was demonstrated in this study that ASSR was of hypoglycemic and hypolipidemic properties in experimental type 2-like diabetic rats. Therefore, seed residues of sea buckthorn and its aqueous extract could be added as supplement in health-care food or drugs or combined with other hypoglycemic drugs.
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
