Antihyperglycemic Effect of Aqueous Extract of Boscia Senegalensis in Rabbits

Abstract

Introduction Diabetes is a serious chronic disease that occurs when the pancreas does not produce enough insulin or when the body does not properly use the insulin produced. A distinction is made between type 1 and type 2 diabetes, which increases the risk of death. This work aims to study the anti hyperglycemic effect of B. senegalensis used in Chad to fight type II diabetes and metabolic syndrome. Methodology The Oral Glucose Tolerance Test was carried out, causing hyperglycemia in rabbits, followed by the incorporation of aqueous extract of Boscia senegalensis in the treatment batch. Then, a toxicity study was carried out using a standard method. Results The results showed that in treated rabbits, the incorporation of aqueous extract of B. senegalensis after glucose administration, led to a drop in blood sugar (1.35mg/dl to 1.22 mg/dl). The increase in blood glucose in control rabbits (1.23 mg/dl to 1.38 mg/dl) due to glucose administration persisted. The ratio of organ weight and body weight of the two lots of rabbits showed no significant difference. Conclusion This study confirmed the safety of B. senegalensis extract and reduce significantly the rate of glucose in the blood fighting against type 2 diabetes.