Abstract
The effect of dietary feeding of hydroxyethyl methylcellulose (HEMC) and hydroxypropyl methylcellulose (HPMC) on the glucose metabolism and antioxidative status in mice under high fat diet conditions was investigated. The mice were randomly divided and given experimental diets for six weeks: normal control (NC group), high fat (HF group), and high fat supplemented with either HEMC (HF+HEMC group) or HPMC (HF+HPMC group). At the end of the experimental period, the HF group exhibited markedly higher blood glucose and insulin levels as well as a higher erythrocyte lipid peroxidation rate relative to the control group. However, diet supplementation of HEMC and HPMC was found to counteract the high fat-induced hyperglycemia and oxidative stress via regulation of antioxidant and hepatic glucose-regulating enzyme activities. These findings illustrate that HEMC and HPMC were similarly effective in improving the glucose metabolism and antioxidant defense system in high fat-fed mice and they may be beneficial as functional biomaterials in the development of therapeutic agents against high fat dietinduced hyperglycemia and oxidative stress.
Highlights
Hydroxypropyl methyl cellulose (HPMC), a synthetically modified natural polymer, is a viscous soluble fiber widely used as a thickener, emulsifier, stabilizer, and gelling agent in the food and pharmaceutical industries [1]
NC, normal control diet; HF, high fat diet; HF+hydroxyethyl methylcellulose (HEMC), HF supplemented with HEMC; HF+hydroxypropyl methylcellulose (HPMC), HF supplemented with HPMC
The present study demonstrated, for the first time, the hypoglycemic effect of HEMC, indicating that it may be beneficial in the treatment and management of high fat diet-induced hyperglycemia
Summary
Hydroxypropyl methyl cellulose (HPMC), a synthetically modified natural polymer, is a viscous soluble fiber widely used as a thickener, emulsifier, stabilizer, and gelling agent in the food and pharmaceutical industries [1]. While various researches have been conducted on the possible therapeutic potential of HPMC in the management of hypercholesterolemia and hyperglycemia, there have been no published reports yet on the physiological functions of HEMC. Chronic consumption of a high fat diet leads to obesity, hyperlipidemia and hyperglycemia [8,9]. Studies have shown that individuals with higher dietary fat intake were more prone to develop glucose metabolism disorder and type 2 diabetes mellitus than those with lower fat intake [10]. Our recent investigation on HPMC and HEMC revealed that both of these dietary fibers were effective in suppressing high fat-induced hyperlipidemia in mice [12]. This study was conducted to determine whether HEMC, as well as HPMC, could improve the glucose metabolism in mice fed with a high fat diet. The comparative effects of these dietary fibers on the antioxidative defense system in mice were investigated
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