Abstract
<p class="Abstract">The core objective of this study was to investigate the in vitro anti-oxidant and antihyperglycemic effect of the ethanol extract of <em>Parmotrema </em>hababianum in streptozocin-induced diabetic rats for 42 days. The extract showed nearly all anti-oxidant activities with maximum presence. The treatment with extract in diabetic rats at the dosage level of 100 and 200 mg/kg, which is compared with diabetic control and glibenclamide at a dosage level of 4 mg/kg and the biochemical parameters such as blood glucose, total cholesterol, triglycerides, HDL, LDL, insulin, total protein, urea and creatinine were assessed. The extract showed positive correlation (p&lt;0.001) in reducing blood glucose level as compared to the control. Moreover, there was a significant (p&lt;0.01) decrease in TC, TG, LDL, SGPT, SGOT, urea and creatinine level and significant (p&lt;0.01) increase in HDL and insulin level. Thus, the results of this study show considerable efficacy in curing diabetes with potent anti-oxidant and anti-hyperglycemic activity.</p><p class="Abstract"><strong>Video Clip of</strong>:</p><p class="Abstract"><a href="https://youtube.com/v/Lw2vvLpKNTE">Methodology</a>: 6 min 12 sec</p>
Highlights
Diabetes mellitus is considered as a greater health concern all over the world
We have investigated the anti-oxidant and antidiabetic potential of P. hababianum
The scavenging of free radicals produced in our body is performed by the action of anti-oxidant molecules (Oboh et al, 2007)
Summary
Diabetes mellitus is considered as a greater health concern all over the world. Free radicals are reactive oxygen species (ROS) that are integrated into the physiology of the human system (Shih et al, 2006). An excess production of these ROS leads to oxidative stress to the normal cellular functions. Anti-oxidant molecule protects the cellular components from the oxidation effect of free radicals (Jeya et al, 2015). They are important in protecting against diseases, such as arthritis, diabetes mellitus, carcinogenesis and cardiovascular diseases, developed in response to oxidative stress (Sangameswaran et al, 2009)
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