Abstract
ObjectiveTo evaluate the antidiabetic and hypolipidemic activity of aqueous root extract of Icacina senegalensis (I. senegalensis) in alloxan-induced diabetic rats. MethodBlood glucose levels of alloxan-induced diabetic rats were monitored after the administration of I. senegalensis extract (100, 200 and 400 mg/kg) to diabetic rats for 14 d. Different biochemical parameters, serum cholesterol, serum triglyceride, high density lipoprotein, low density lipoprotein and very low density lipoprotein were also examined. ResultsTreatment of alloxan diabetic rats with the extract showed significant (P<0.05) activity. The activity of the extract was comparable to that of the standard drug, glinbeclamide. ConclusionsThe results suggest that the root extract of I. senegalensis possesses antidiabetic and hypolipidemic properties, which might be a potential source for isolation of new orally active agent in the treatment of diabetes and its associated complications.
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