Antihyperglycemic activity of Rhizophora apiculata Bl. in rats

Abstract

The article reveals the antihyperglycemic activity of the ethanolic extract of the roots of the Rhizophora apiculata in rats (GLM and STZ models). On further fractionation of the ethanolic extract into four fractions, the activity was localized in the chloroform and aqueous fractions. These on purification led to the isolation of 7 pure compounds – lupeol (1), oleanolic acid (2), β-sitosterol (3), palmitic acid (4), β-sitosterol-β-D-glucoside (5), inositol (6), and pinitol (7). The inositol and pinitol, two of the pure compounds, showed promising activity in STZ model at 100 mg kg−1 dose level.