Abstract
The aim of this study was to identify the chemical group, evaluate an acute toxicity study and analyze the effect of aqueous extract Khaya senegalensis (Meliaceae), on experimentally induced hyperglycemic condition in rats. The phytochemical study of the aqueous extract of Khaya senegalensis revealed the presence of active secondary metabolic compounds such as flavonoids, polyphenols, catechol tannins, quinones, saponins, sterols and terpenes. The stem bark of Khaya senegalensis was used for acute toxicity study by gavage in Swiss mice. The aqueous extract of Khaya senegalensis (AEKS) at the dose of 35±5 mg/kg administrated by gavage showed that all the mice treated were living after 24 hours. The lethal dose obtained by intraperitoneal administration with graded doses to the mice was 1778 mg/kg. This extract could be non-toxic. The study of AEKS activity on blood glucose in rats showed a significant (p <0.01) the concentration of glucose in the serum of the treated rats with the AEKS (96.2 ± 30 mg/dl) and Glibenclamide (92.4±10 mg/dL), compared to glucose concentrations in the serum of hyperglycemic rats (197.1 ± 50 mg/dl). Thus, the study showed hypoglycemic activity of aqueous extract of Khaya senegalensis. In conclusion, the administration of AEKS causes hypoglycemic activity in rats given oral glucose load. Hypoglycemia this is due to the presence of active chemical groups in the extract of this plant, such as flavonoids, catechin tannins, polyphenols, quinones, sterols and terpenes. These results confirm the therapeutic indication in traditional medicine Khaya senegalensis in the treatment of diabetic disease.
Highlights
The lack of health coverage in Sub-Saharan countries and the high cost of the annual management of the diabetic patient excluding complications, explain the renewed interest in the traditional [18] medicine
Catechin tannins and quinones that we identified in aqueous extract of Khaya senegalensis (AEKS) have hypoglycemic activity in the ethanol extract 70% Rauvolfia vomitoria (Apocynaceae) during a adminitration oral glucose load of 4g/kg/ov among wistar [13] rats
The phytochemical screening showed in the aqueous extract of Khaya senegalensis the group of flavonoids, tannins catechic, polyphenols, quinones, sterols and terpenes
Summary
The lack of health coverage in Sub-Saharan countries and the high cost of the annual management of the diabetic patient excluding complications, explain the renewed interest in the traditional [18] medicine. The antidiabetic substances research of plant begun by in vitro methods, in vivo and clinical to develop phytomedicines at affordable prices for the population is booming on all continents. Plant extracts have been used for the treatment of diabetes in Africa, America, Asia, Australia and Europe [3]. The existence of a traditional antidiabetic pharmacopeia for the treatment of diabetic pathology is confirmed by traditional healers and medicine [18]. Khaya senegalensis (Meliaceae), is native to tropical Africa.
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