Diabetes is a chronic disease that affects the bodys ability to utilize the energy found in food. This is a condition in which the pancreas does not produce enough insulin, which the body needs to regulate glucose metabolism. Diabetes mellitus is a complicated health condition with multiple causes and many natural treatment options.In Euphorbiahirtaafzelin, quercitrin, myricitrin,rutin, quercitin, euphorbin-A, euphorbin-B, euphorbin-C, euphorbin-D, 2,4,6-tri-O-galloyl-β-d-glucose, 1,3,4,6-tetra-O-galloyl-β-d-glucose, kaempferol, gallic acid, and protocatechuic acidhave been isolated.Euphorbia hirtahas antidiabetic, antioxidant, antibacterial, sedative, anxiolytic, anti-epileptic, anti-inflammatory, analgesic, antipyretic, antihistamine, anti-asthmatic, anti-diabetic, anti-cancer, and wound healing properties. It exerts healing, gastrointestinal, diuretic, antiparasitic, immunological, hepatoprotective, galactose-producing, and angiotensin-converting enzyme inhibitory effect.Medicinal plants have been reported to be useful for diabetes all over the world and are empirically used as antidiabetic and antihyperlipidemic agents. Therefore, the present study was designed to investigate antihyperglycaemic effect of Euphorbia hirtawith different doses. The antihyperglycaemic properties of methanolic extract of the Euphorbia hirtawas evaluated in Swiss albino mice in order toscientifically validate its traditional therapeutic use with the different doses as per bodyweight. In this experiment, among all the doses, the methanolic extract of Euphorbia hirta decrease the blood sugar level. The low dose (50 mg/kg body weight) decrease the glucose level compared to control but not as much as standard value. Oral administration of methanolicextract of Euphorbia hirtadoses equivalent to 100, 200 and 400 mg/kgbody weight produce significantantihyperglycaemic effects respectively.

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