Abstract
Antihyperglycaemic and Antihyperlipidaemic Activities of Ethanol Leaf Extract of Eleusine coracana (Linn.) Gaertn. in Alloxan-Induced Hyperglycaemic Rats
Highlights
Alloxan administration resulted in significant (p < 0.05) elevation of low-density lipoprotein (LDL), TG, total cholesterol (TC) and decline in high-density lipoprotein (HDL) levels when compared to normal rats
Diabetes mellitus is a chronic metabolic disease characterized by raised blood glucose levels, which leads over time to significant impairment to the heart, kidneys, eyes, blood vessels and nerves (WHO, 2016)
The antihyperglycaemic and antihyperlipidaemic activities of E. coracana leaf extract as observed in this study may be attributed to the presence of some of these bioactive principles
Summary
Diabetes mellitus is a chronic metabolic disease characterized by raised blood glucose levels, which leads over time to significant impairment to the heart, kidneys, eyes, blood vessels and nerves (WHO, 2016) It is categorized seventh, among the important causes of death globally and it is considered third when its complications are taken into account (Trivedi et al, 2004). Herbal products are extensively used in the management of diabetes mellitus and recently there is a renaissance of interest in medicinal plants with antihyperglycaemic potential (Mamun-orRashid et al, 2014). One of such plants widely used in Nigeria in the management of diabetes mellitus is Eleusine coracana. This study was carried out to investigate the antihyperglycaemic and antihyperlipidaemic potentials of the ethanol leaf extract of E. coracana in alloxan-induced hyperglycaemic rats
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