Antihyperglicemic effectiveness comparison of ethanol extract of soursop leaf (Annona muricata L.) againts acarbose in streptozotocin-induced diabetic white rats

Abstract

Type 2 diabetes mellitus is major health problem worldwide, including in Indonesia. Acarbose, an alpha glucosidase inhibitor, is one of oral pharmacologic management commonly used in clinical practice with potent side effect in long-term use. Flavonoid-and-tannins containing soursop leaf can stimulate insulin secretion and repair beta pancreatic cell dysfunction. This study was aimed to investigate the comparison on antihyperglycemic effect between ethanol extract of soursop leaf (Annona muricata L.) and acarbose in streptozotocin-induced diabetic white rats. This sudy was experimental research with pre- and post-test control group design enrolling 30 hyperglycemic white male rats. They were divided into 2 control groups (C(+) was given by aquades and C(-) was given by acarbose) and 3 treatment groups (P1 was given 10 mg/200gBW extract, P2 was given 20 mg/200gBW extract, and P3 was given 30 mg/200gBW extract). Data analysis was using paired-T test. This study showed that there is a significant decrease in blood glucose levels in P1, P2, and P3 (95.08 mg/dL, 113.31 mg/dL, and 125.17 mg/dL; p<0.05). Ethanol extract of soursop leaf has antihyperglycemic effect in dose-dependent response. The 30 mg of ethanol extract of soursop leaf is not inferior to 1.8 mg of acarbose in antihyperglycemic effect.